Novel mechanisms to inhibit HIV reservoir seeding using Jak (Janus kinase) inhibitors [PLoS Pathogens, 21 Dec 2017 — free full-text]

Author summary HIV persists in infected hosts in a small number of CD4 + memory T cells as latently infected proviruses. Homeostatic cytokines, which play a major role in the maintenance of T cell memory, also enable the persistence of latently infected cells. The pathways downstream of these homeostatic cytokines are well known and drugs that target these pathways have been developed and have been safely used in inflammatory diseases and in myelofibrosis. We have used these drugs to inhibit the maintenance and the spread of HIV infected cells carrying latent forms of the virus. We show that ruxolitinib and tofacitinib will inhibit the expansion of these cells and their capacity to infect other cells upon reactivation. This class of drugs is currently being tested in clinical trials.

http://dx.plos.org/10.1371/journal.ppat.1006740

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15 Science-Based Health Benefits of Oxaloacetate

Oxaloacetate is a relatively understudied compound with a high potential. Studies have shown that Oxaloacetate supplements can help reduce aging, help with brain injuries and neurodegenerative diseases, and help with treatment of Cancers. For info on my handpicked favorite substances check out my book SelfHacked Secrets. To receive the first chapter absolutely free click here. ?

https://selfhacked.com/blog/oxaloacetate-16-scientifically-proven-benefits-oxaloacetate/

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Getting outside is a prescription for better health – A breath of fresh air can be physically healing, and a group of physicians is now putting the idea into practice by prescribing time outdoors for some patients.

Going for a jog or even a long walk outdoors has well-known benefits to our health. But research suggests that, even without much physical activity, just stepping into the natural world can enhance well-being. Now some doctors are starting to prescribe time outdoors for their patients.

https://www.pri.org/stories/2017-12-30/getting-outside-prescription-better-health

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Energy for new year’s resolutions

Go to the store, and you'll see a multitude of vitamins, herbs, and other supplements touted as energy boosters. Some are even added to soft drinks and other foods. But there's little or no scientific evidence that energy boosters like ginseng, guara...

https://www.health.harvard.edu/energy-and-fatigue/9-tips-to-boost-your-energy-naturally

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