Parkinson’s disease symptoms improve with singing, study finds

An Australian first trial involving more 70 people with Parkinson's disease which found singing regularly improves mobility, culminates in a joyous performance at the Queensland Conservatorium.

http://www.abc.net.au/news/2018-02-04/parkinsons-singers-trial-australian-first/9394346?section=health

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Fish oil may not be as healthy as you think, new study suggests… Is this valid???

Fish oil has often been touted as an important part of a healthy diet, regularly praised for its numerous benefits. However, new research suggests that consistent fish oil consumption could lead to serious liver problems.

http://www.wsbtv.com/news/national/hot-topics/fish-oil-may-not-be-as-healthy-as-you-think-new-study-suggests/695496928

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Drug cures Zika-induced microcephaly in animals injected with human neurons

Zika virus (ZIKV) is a mosquito-transmitted flavivirus with a causative link to microcephaly, a condition resulting in reduced cranial size and brain abnormalities. Despite recent progress, there is a current lack of in vivo models that permit the study of systemic virus on human neurons in a developing organism that replicates the pathophysiology of human disease. Furthermore, no treatment to date has been reported to reduce ZIKV-induced microcephaly. We tested the effects of ZIKV on human induced neural stem cells (hiNSCs) in vitro and found that infected hiNSCs secrete inflammatory cytokines, display altered differentiation, and become apoptotic. We also utilized this in vitro system to assess the therapeutic effects of niclosamide, an FDA-approved anthelminthic, and found that it decreases ZIKV production, partially restores differentiation, and prevents apoptosis in hiNSCs. We intracranially injected hiNSCs into developing chicks, subjected them to systemic ZIKV infection via the chorioallantoic membrane (CAM), a tissue similar in structure and function to the mammalian placenta, and found that humanized ZIKV-infected embryos developed severe microcephaly including smaller crania, decreased forebrain volume and enlarged ventricles. Lastly, we utilized this humanized model to show that CAM-delivery of niclosamide can partially rescue ZIKV-induced microcephaly and attenuate infection of hiNSCs in vivo . [This article has an associated First Person interview with the first author of the paper][1]. [1]: http://bio.biologists.org/lookup/doi/10.1242/bio.031807.supplemental

http://bio.biologists.org/content/7/1/bio031807.long

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Abuse-Deterrent Opioids and the Law of Unintended Consequences

The United States has seen a surge in deaths from overdoses of opioids, including both prescription drugs and illegal opioids such as heroin. Nonmedical users and abusers often obtain prescription opioids diverted from the legal to the illegal market. In the hope of reducing opioid use, abuse, and overdoses, policymakers have focused on developing and promoting tamper-resistant or abuse-deterrent formulations (ADFs) ...

https://www.cato.org/publications/policy-analysis/abuse-deterrent-opioids-law-unintended-consequences

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What Happens When a Driver Kills Someone While Fiddling With A Cellphone? Often, Not Much

An informal review by FairWarning of prosecutions of distracted drivers ? cases gleaned from news reports over the last five years that involved more than 100 deaths overall ?- found that light punishment is the norm. Few were sentenced to serve for more than a month or two, or given fines above $1,000.

https://www.fairwarning.org/2018/02/distracted-driving-prosecutions/

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